L-methylfolate for SSRI resistance

According to a review (abstract NR3-46) presented at the 2010 Annual Meeting of the New Orleans American Psychiatric Association (APA) and announced by MedScape, L-methyl phosphate is a clinically approved clinical regulation for drug stimulant therapy as drug monotherapy. More powerful than that. Red Oak Psychiatric Associates, experts in Houston, have conducted a significant review of the effectiveness of serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIsitors), specifically from the effect of L-methylvipolate (PL). Directed the record audit study. ) Indicating grief. Blend Bunch has a more significant upgrade in fuzzy side effects than monotherapy, and the improvement is 23% faster.

We found that adding L-methyl folate to the energizer at the beginning of the treatment had significant benefits for these patients, said Lawrence D. Ginsberg, MD, Chief Examiner. More limited opportunities for progress strongly suggest that initiating blending techniques is an additional time-efficient method compared to energizer monotherapy.

The test team evaluated the clinical records of 242 adult patients who received stimulants with SSRI or SNRI or with Joplin at 7.5 to 15 mg. A significant number of patients who received mixed therapy showed a two-point reduction in the depression on the multi-day time point, contrast, and monotherapy. Blend treatment was more successful in patients with high-intensity scores at the standard level. Similarly, the suspension of energizer treatment was slowed down due to the negative possibilities.

The critical point is that we should be careful about folate deficiency and try clinical food types in patients who are unresponsive to conventional medications. Similarly, even if there are no accurate, precise results from such a dose, we should be careful to examine and investigate whether it is related to the recommended medication.

New research suggests that patients with SSRI-safe grief may benefit from increased treatment with the clinical food L-methyl folate. The review, published in the American Journal of Psychiatry, demonstrates the significant response and tolerance of L-methyl‌folate (available by solution under the brand name Decline in the U.S.) in patients with major depressive disorder (MDD). Their first round of stimulant monotherapy will sterilize 66% of people living with grief. However, many are unaware that the specific metabolic specificity that prevents a satisfactory response to treatment with conventional serotonin reuptake inhibitors (Ssri’s) is far from all.

Some reviews

Dr George Papacostas said, “The original way of dealing with treatment may require Decline ® discolouration, which is forced in patients unresponsive to conventional Ssri, is moderately protected and, unlike practically all alternatives, is permanent.”, Leading producer of reviews. “The viability of the cell was demonstrated to some extent in a randomized controlled baseline analysis at 15mg per day, and we look forward to seeing how this contributes to a specific subset of the population suffering from SSRI-safe depression.” “The initial results of this clinical are exceptionally reassuring,” said Dr Maurizio Fawa, lead expert on the review. “It would be encouraging to see additional exploration, including L-methyl folate, as an adjunctive treatment for MDD. Although it has been demonstrated to help patients achieve an unmatched response in the treatment of dementia, it is a breakthrough in this field. There may be a real specific purpose. “


There were 223 patients with SSRI-safe MDD who were twice screened, and 15mg L-methylfolate daily may be a valuable treatment option for SSRIs and those who do not respond with MDD, but 7.5mg daily seems to be a valuable treatment option. By all accounts, this is not enough to treat MDD.

In the primary ensemble, 148 short-term patients with SSRI-safe MDD were divided into two 30-day time frames in a 60-day multi-focus study (stages I and II). Patients were randomly modified to receive adjuvant L-methyl folate at 60 days (7.5 mg/day, phase I; 15 mg/day, stage II) in a 2: 3: 3 regimen, followed by adjuvant sham treatment (7.5 mg/day) for 30 days after adjuvant L-methyl folate ) Auxiliary sham treatment for 30 days or 60 days. SSRI fractions were kept constant during the double-blinding of the review. Subsequent onset, with a total of 75 patients, was not separated from the previous plan, except the objective fraction of adjuvant L-methyl folate at 15 mg/day in two phases.

The main start showed no difference between the additional L-methyl‌folate 7.5 mg/day and the auxiliary sham treatment. The subsequent initial results were presented with superior results on the additional L-methyl‌folate 15 mg/day and the co-administered auxiliaries. With mock treatment. -Necessary result measurements and various auxiliary result measures. Most patients taking adjuvant L-methyl folate 15 mg daily completed the response within 30 days (response: 50% reduction in burping expressions) and adjuvant sham therapy (P = 0.04, P = 0.04, P = 0.05 separately). The expected number for treatment is somewhere in the range of 5 and 6 for L-methyl‌folate 15 mg/day.

There is no measurable, significant difference between L-methylpholate and Sham treatment-treated patients due to the unfavourable possibilities at the end.